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Figure 4 (Upper panel) Pressure-volume diagrams during sinus rhythm (SR) and pacing at the low, mid-, mid-high, and high-right ventricular (RV) septum. (Lower panels) Mean values ± SD of maximal rate of rise of left ventricular (LV) pressure (LVdP/dtpos) and stroke work (SW) during pacing at the RV apex and the various RV septal sites relative to SR. Differences in SW and LVdP/dtpos between the five pacing modes were not statistically significant, but SW was significantly lower than SR during pacing at all five sites, and LVdP/dtpos was significantly below SR during low and high septal pacing.