Click on image to view larger version.

Figure 2 The forearm blood flow (FBF) variations in response to brachial artery acetylcholine (ACh) infusion. Acetylcholine (20, 40, and 80 µg/min) was infused into the brachial artery, and FBF variations (expressed in ml/min per 100 ml) were recorded using venous occlusion plethysmography. The FBF variations are shown before and after treatment in the S 18886-treated group (top) and placebo group (bottom). Statistical analysis was performed on the area under the curve of FBF. p = 0.02 for comparison of values before and after treatment in the S 18886 group (paired t test); p = 0.03 for comparison between values recorded after treatment between the S 18886 and placebo groups (analysis of covariance).