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Figure 3 Hierarchical clustering using Cluster and Treeview. Data for these programs require different names for each sample, hence 1-3 represent nonischemic patients and 4-6 represent ischemic patients. (A) Hierarchical clustering of raw data; note the segregation of the nonischemic patients and relative similarity of ischemic patients post-left ventricular assist device (LVAD). (B) Hierarchical clustering of raw data from the 530 genes found to be significantly regulated by the paired t test. Note the distinct separation of pre- and post-LVAD, along with segregation of the nonischemic and ischemic patients pre-LVAD.