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Figure 2 This figure has been redrawn according to Michele et al. 2000 (26), and represents the predicted coiled-coil structure of the alpha-tropomyosin gene (TPM1) alpha helix. The positions a to g represent the amino acids sequence of the heptad repeat that stretches along the entire alpha-tropomyosin protein. The view starts from the N-terminus (position a) of the tropomyosin protein going down the axis of the tropomyosin dimer (position g). The dotted lines represent the stabilizing interaction of charged amino acids between two tropomyosin molecules to form the coiled-coil dimer. Mutations associated with familial hypertrophic cardiomyopathy (bold) or dilated cardiomyopathy (italic) are indicated in the figure. The mutation Glu62Gln identified in this study is underlined.