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Figure 1 Five generation pedigree of the familial hypertrophic cardiomyopathy family. Pedigree symbols: squares = males; circles = females; symbols with diagonal slash = deceased family members; filled symbols = individuals with documented hypertrophic cardiomyopathy; dot within symbol = obligate carrier of the genetic defect; unfilled symbols = individuals without cardiac hypertrophy. Underneath the symbols are indicated the age (years) of sudden death and the genetically defined carriers of the mutation with E62Q (Glu62Gln). Bars = the haplotypes and numbers the alleles length (in basepairs) of the markers D15S159 (upper) and D15S993 (lower); filled bars = the risk haplotype 165 to 181.