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Figure 2 Changes in age-adjusted forearm blood flow responses to an intrabrachial artery infusion of the endothelial-dependent vasodilator acetylcholine in the normotensive (NT) subjects (A and C) and in the uncomplicated patients with mild-to-moderate essential hypertension (PH) (B and D) divided according to the T^-786C (A and B) and Glu298Asp (C and D) endothelial nitric oxide synthase (eNOS) genotypes. A significantly blunted response was seen in the PH patients as compared with the NT subjects. In addition, an enhanced response was seen in the PH patients who were TT homozygous (n = 30) at the T^-786C eNOS genotype, as compared with the TC (n = 69) and CC (n = 38) genotypes. At variance, no significant differences were seen between the PH patients and NT subjects classified according to the Glu298Asp (G⁸⁹⁴T) eNOS genotype. Mean ± SEM. *p < 0.01; **p < 0.001 by analysis of variance and post-hoc Bonferroni test of TT versus the other genotypes.