Click on image to view larger version.

Figure 6 Effect of calcium channel antagonists and antioxidants on caspase-3 activity. Myocytes were treated with 10^–6 mol/l of doxorubicin in the presence or absence of amlodipine (10^–6 mol/l), nifedipine (10^–6 mol/l), probucol (10^–4 mol/l), ascorbic acid (5 x 10^–5 mol/l), or alpha-tocopherol (10^–4 mol/l). Caspase-3 activity was determined as described in the Methods section (n = 10). *p < 0.005 vs. control. p < 0.001 vs. doxorubicin. p < 0.0005 vs. doxorubicin. p < 0.0001 vs. doxorubicin.