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Figure 5 Inhibition of tissue factor (TF) by TF pathway inhibitor (TFPI) reduces thrombus formation and intima hyperplasia after porcine coronary angioplasty (49). Administration of TFPI during coronary angioplasty prevented acute thrombus formation (B). Note the presence of mural thrombus (black arrow) and intramural hemorrhage (white arrow) in the control animal (A) despite similar vascular injury, as confirmed by the disruption of the internal elastic lamina and part of the media present in both A and B. Similarly, TFPI significantly reduced the proliferative response in porcine coronary arteries (D) 28 days after angioplasty as compared with control animals (C). Adapted from Roque M, et al. J Am Coll Cardiol 2000;36:2303–10 (31).