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Figure 6 The Trial on Reversing Endothelial Dysfunction (TREND) investigated the effects of six months of treatment with the ACE inhibitor quinapril on a target coronary artery segment (<40% diameter stenosis) in patients who underwent nonsurgical interventions for >50% stenosis in one to two other segments. At baseline, the endothelium-dependent vasodilator acetylcholine elicited a paradoxical vasoconstriction; quinapril resulted in a significant improvement in the response to acetylcholine (p < 0.014 vs. placebo). (Reprinted from Pepine JC, et al. Improved endothelial function with angiotensin-converting enzyme inhibitors. Am J Cardiol 2002;79:29–32. Copyright 2002, with permission from Excerpta Medica Inc.)