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Figure 1 Systolic blood pressure (SBP) values in the five experimental groups before and during the treatment with placebo (open squares), bosentan (closed circles), irbesartan (closed down triangles), BMS-182874 (open triangles), and irbesartan plus BMS-182874 (closed up triangles). Starting from the end of the first week of treatment, SBP was significantly lower (p < 0.001) in the irbesartan group compared with all other groups. In the irbesartan plus BMS-182874 group, SBP was significantly (p < 0.01) lower only at the end of the third week compared with the bosentan and BMS-182874 groups.