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Figure 3 Effects of the –129C/T polymorphism on GCLC promoter activity in human umbilical vein endothelial cells. The transfected cells were incubated for 18 h with H₂O₂ (100 µmol/l) or phosphate-buffered saline (PBS) (as a time control). Promoter activity is expressed as relative luciferase activity normalized to Renilla activity. Data are presented as the mean value ± SEM from eight independent experiments. *p < 0.05, p < 0.01. Open bars = –129C; solid bars = –129T.