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Figure 3 In vivo dose-response of the ACT as a function of the cumulative doses of UFH (circles) or dalteparin (squares). Patients (n = 15) initially received dalteparin (40 + 40 IU/kg 5 min apart, for a total of 80 IU/kg), and then, following a 12-h delay to allow elimination of dalteparin and return of the ACT to baseline, received UFH (40 + 30 U/kg 5 min apart, for a total of 70 U/kg). Data presented as mean ± SD. Abbreviations as in Figure 2.