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Figure 2 Haplotype analyses of a pedigree with familial atrial fibrillation (AF) and early features of dilated cardiomyopathy. Haplotypes were constructed at a locus for familial AF (a) and loci for familial dilated cardiomyopathy, sinus node dysfunction, conduction system disease, and AF on chromosomes 3p22-p25 (b) and 1q21 (c), where the lamin A/C gene is located. The affected individuals do not inherit the same haplotype, excluding a disease gene at these loci. FAF = multi-generation families with autosomal dominant atrial fibrillation. Continued on next page