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Figure 2 Mean values (±SEM) of prothrombin activation fragment 1+2 plasma levels for the placebo and recombinant nematode anticoagulant protein c2 (rNAPc2) dose groups. No clopidogrel treatment before percutaneous coronary intervention. The following statistically significant differences were found between the rNAPc2 dose groups and placebo (Bonferroni-corrected p values, including five comparisons at each time point): *p < 0.05: 3.5 and 3.5 vs. placebo; p < 0.01: 7.5 vs. placebo; **p < 0.05: 5.0 vs. placebo; p < 0.01: 3.5 vs. placebo; p < 0.001: 3.5, 7.5, and 10.0 vs. placebo; ***p < 0.05: 3.5, 3.5, and 5.0 vs. placebo; p < 0.001: 7.5 and 10.0 vs. placebo. Solid diamond = placebo; open square = 3.5 µg/kg; x = 3.5 µg/kg; solid triangle = 5.0 µg/kg; open triangle = 7.5 µg/kg; open circle = 10.0 µg/kg.