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Figure 4 Echocardiographic studies at baseline and five weeks after MI demonstrating increased end-diastolic and end-systolic diameters indexed to bodyweight (EDD/BW and ESD/BW), and a decreased fractional shortening (FS) in the infarcted animals. E2 significantly increased both EDD/BW and ESD/BW post-MI. E2 had no effect on fractional shortening. Open circles = placebo; filled circles = E2. Broken lines = sham; solid lines = MI. *p 0.05 placebo-MI vs. placebo-sham and E2-MI vs. E2-sham; p 0.05 E2-MI vs. placebo-MI. BL = baseline; FU = follow-up; other abbreviations as in Figure 1.