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Figure 3 Effect of oral treatment with isosorbide mononitrate (ISMN) on nitric oxide (NO)-dependent vasodilation induced by (A) acetylcholine (ACh) and (B) S-nitroso-N-acetyl-D,L-penicillamine (SNAP) in aortic rings. The concentration response curves are not significantly different for ACh or SNAP between the three groups (p > 0.05 by analysis of variance), indicating that even in ISMN-tolerant animals, NO-dependent vasodilation is maintained.