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Figure 1 Pedigrees of family 1 (A) and family 2 (B). An arrow indicates the probands in each family. Solid symbols indicate clinically affected individuals, and those tested for the A4300G mitochondrial deoxyribonucleic acid mutation have an asterisk. In family 1, there is a less extensive family tree, and from the pedigree, either an X-linked or autosomal-recessive pattern of inheritance is possible. However, there was no clinical or pathologic evidence of Fabry disease in either family.