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Figure 2 Effect of verapamil infusion on the adenosine-induced (250 µg/kg/min) increase in microsphere-determined absolute regional myocardial blood flow in dogs with a critical left anterior descending coronary artery (LAD) stenosis. With verapamil, there was a severe impairment of the adenosine-mediated increase in normal left circumflex coronary artery (LCx) zone flow, resulting in a marked diminution of the LAD to LCx zone flow disparity. Data are mean ± SEM of two experiments. *p < 0.05 vs. baseline.