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Figure 1 Mean ± SEM hemodynamic responses to incremental boluses of urocortin and a vehicle control in eight normal sheep (left panel) and eight heart failure sheep (right panel). Baseline data points represent the mean of four samples taken in the hour preceding treatment. Significant differences (compared with time-matched control) are shown by: *p < 0.05; **p < 0.01; p < 0.001.