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Figure 2 Infarct size as a percentage of the area at risk (AAR). Sarpogrelate (SG) pretreated group: SG was infused at a rate of 5 or 10 mg/kg/h starting 10 min before ischemia until 20 min after reperfusion for 60 min. Sarpogrelate post-treated group: SG was infused at a rate of 10 mg/kg/h starting 10 min before reperfusion until 50 min after reperfusion for 60 min. Sarpogrelate (5 and 10 mg/kg/h) reduced the infarct size, which was blocked by a selective protein kinase C inhibitor, chelerythrine, or a mitochondrial adenosine triphosphate sensitive potassium channel blocker, 5-hydroxydecanoate (5-HD). Chelerythrine or 5-HD alone did not affect the infarct size. *p < 0.05 versus control.