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Figure 1 (A) Myocardial interstitial serotonin levels before, during 30-min ischemia, and during two consecutive 30-min reperfusions in the absence and presence of sarpogrelate in an in vivo model. Myocardial interstitial serotonin levels were significantly increased during ischemia and the first 30-min reperfusion. These increases were inhibited by sarpogrelate. Vertical axis: eluate concentration (ng/ml). *p < 0.05 versus baseline control. (B) Myocardial interstitial serotonin levels before, during 30-min ischemia, and during 30-min reperfusion in an isolated heart model with and without sarpogrelate. Myocardial interstitial serotonin levels were significantly increased during ischemia without sarpogrelate. Sarpogrelate completely abolished the increase in myocardial interstitial serotonin during ischemia. Vertical axis: eluate concentration (ng/ml). *p < 0.05 versus baseline control.