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Figure 4 Scatterplot demonstrating the inverse correlation between the change in pulmonary artery pressure (PAP) and exhaled nitric oxide (eNO) in response to acute administration of milrinone (r = –0.61, p = 0.027). A decrease in PAP caused by milrinone was associated with a rise in eNO, consistent with the inverse relationship depicted in Figure 1. In patients in whom PAP remained unchanged or rose slightly with milrinone, eNO actually fell, consistent with the notion that these patients have a defect in nitric oxide pathway activity.