Click on image to view larger version.

Figure 2 Scatterplot demonstrating the correlation (r = – 0.81, p < 0.00001) between levels of exhaled nitric oxide (NO) and systolic pulmonary artery pressure (PAP) in patients with compensated heart failure (open circles). Linear regression lines with 95% confidence intervals are depicted for patients with compensated heart failure. Patients with decompensated heart failure at baseline (solid squares) deviated from this curve, did not exhibit an inverse correlation between eNO and PAP, and eliminated the linear relationship between PAP and eNO. The relationship between these two variables was restored toward normal after tailored therapy (solid inverted triangles). With inclusion of the post-treatment data, the linear regression between NO and PAP persisted (r = –0.66, p = 0.00005).