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Figure 1 Representative micrographs of carotid endarterectomy specimens form CC (A and C) and CT (B and D) genotype carriers. A prevalence of macrophages (stained with HAM56) was found in specimens obtained from the CC carriers, whereas smooth muscle cells (SMCs) (stained with SM-E7) were more numerous in specimens obtained from the CT carriers. The insets in B and C display, at high magnification, the staining of plaque areas for macrophages and SMCs, respectively. The number of cells per area unit was assessed by computerized image analysis (see Methods and ref. 10). m = tunica media; pl = atherosclerotic plaque. Bar = 80 µm. Magnification x20 Planapo objective.