Click on image to view larger version.

Figure 1 (A) Effect of acute hyperhomocysteinemia on the myocardial blood flow (MBF) response to adenosine. This figure depicts MBF at rest and during infusion of low and high dose adenosine, after placebo and during methionine-induced hyperhomocysteinemia (METH). The adenosine dose response curve is significantly impaired during methionine vs. placebo (p < 0.05, ANOVA). (B) Acute hyperhomocysteinemia impairs the coronary microvascular dilator response to adenosine. This figure depicts the MBF response to the low and high doses of adenosine. The coronary microvascular dilator response to low dose adenosine was significantly blunted during METH (p < 0.05). In contrast, the microvascular dilator response to high dose adenosine was unaffected.