Click on image to view larger version.

Figure 6 Reversal of chronic heart failure (CHF)-induced endothelial dysfunction by pharmacologic inhibition of poly(ADP-ribose) polymerase (PARP) in rats: epinephrine-induced contractions (middle), acetylcholine-induced endothelium-dependent relaxation (upper), and sodium nitroprusside (SNP)-induced endothelium-independent relaxations (lower). Each point of the curve represents mean ± 95% confidence interval of 7 to 10 experiments in vascular rings. *p < 0.05 vs. S; #p < 0.05 vs. CHF. S = sham.