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Figure 3 Effect of pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase on cardiac remodeling and lung weight in rat model of chronic heart failure (CHF) induced by permanent ligation of left anterior descending (LAD) coronary artery. Left ventricular (LVW), right ventricular (RVW), left atrial (LAW), right atrial (RAW), and lung (LungW) weights in sham (S), PJ34-treated (for 10 weeks) sham (S + PJ34), CHF and PJ34-treated (for 10 weeks) CHF (CHF + PJ34) rats. Results are mean ± 95% confidence interval of 8 to 10 experiments in each group. The weight of each cavity and lung was normalized to the length of the right tibia. *p < 0.05 vs. S; #p < 0.05 vs. CHF.