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Figure 4 Paraffin sections of case 1 and normal control case using alkaline phosphatase conjugated antibodies directed against (staining methods as outlined in Methods section): (A) human immunoglobulin (Ig)G demonstrating dense, diffuse deposition of IgG with loss of nuclei and myocardial disarray; (B) human IgM demonstrating focal areas of deposition; (C) human IgG in control case demonstrating mild, diffuse IgG deposition with a normal myocardial muscle pattern with normal, multiple nuclei; (D) human IgM in control case showing normal myocardial muscle pattern with normal, multiple without deposition of IgM (magnification 20 x 0.5).