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Figure 2 (A, B) Salbutamol, given after saline, was associated with a significant decrease in augmentation index (AIx) compared to baseline (AIx; –11.8 ± 3.7%, p < 0.05). When given after N--nitro-monomethyl-L-arginine (L-NMMA) there was no significant change in AIx (–2.0 ± 3.1%). The GTN was associated with a similar significant decrease in AIx after saline (–35.1 ± 3.3%) and L-NMMA (–36.5 ± 3.3%), p < 0.001 by analysis of variance (ANOVA). (C, D) There was no significant effect of either Salbutamol alone or L-NMMA on mean blood pressure (BP). The GTN was associated with a slight decrease in BP in both cases. (E, F) Salbutamol was associated with a significant increase in heart rate, which was blocked after L-NMMA infusion, p < 0.05 by ANOVA.