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Figure 4 Cumulative percentages of all-cause mortality (top), sudden death (middle) and hospitalizations for worsening heart failure (bottom). Low-dose metoprolol controlled-release/extended-release (CR/XL) subgroup is illustrated in the left hand panel and high-dose metoprolol CR/XL group in the right hand panel (Cox-adjusted estimates. Estimates of risk have been obtained from the fitted models explaining why the graphs for the placebo groups have a different appearance in the low- and high-dose subgroups; see Statistical Methods section).