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Figure 1 (A) PQ interval (ms) on baseline ECG for individual patients. Patients with a pore-forming region (alpha-subunit) of the human cardiac sodium channel (SCN5A) mutation were found to have a significantly longer PQ interval than patients without an SCN5A mutation. Solid circle = Brugada syndrome patients with known SCN5A mutation; open circle = mean ± SEM; open square = Brugada syndrome patients without known SCN5A mutation; solid square = mean ± SEM. (B) His to ventricle interval (HV) time (ms) for individual patients. Patients with an SCN5A mutation were found to have a significantly longer HV interval than patients without an SCN5A mutation. Solid circle = Brugada syndrome patients with known SCN5A mutation; open circle = mean ± SEM; open square = Brugada syndrome patients without known SCN5A mutation; solid square = mean ± SEM.