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Figure 4 (Top) Plasma tissue inhibitor of matrix metalloproteinase (TIMP)-1 levels did not change immediately following alcohol injection, but tended to rise at later time points; however, this did not reach statistical significance (p = 0.15). (Bottom) The ratio of plasma matrix metalloproteinase (MMP)-9/TIMP-1 levels was computed for each patient and plotted as a change from baseline values. A significant increase in this ratio occurred by 6 h following alcohol injection. *p > 0.15 vs. time 0; baseline values.