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Figure 1 Kaplan-Meier curves for freedom from major adverse cardiac events according to homocysteine quartiles. There is a strong dose-response relationship between homocysteine quartiles and the incidence of major adverse cardiac events, with 92.0% of patients in the first homocysteine quartile free of any cardiac event, 88.6% in the second quartile, 82.2% in the third quartile, and 78.0% in the fourth quartile (p < 0.05), a relative risk increase between extreme quartiles of 2.8 (95% confidence interval = 1.34 to 5.67).