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Figure 5 Immunohistochemistry for tenascin (A), alpha-smooth muscle actin (-SMAc) (B) and vinculin (C) in the dysfunctional human myocardium from a segment with persistent dysfunction after revascularization. Tenascin immunoreactivity is present in the cardiac interstitium; however, its expression is low in comparison with the extent of fibrosis. In addition, vinculin-positive, -SMAc expressing myofibroblasts are found in the fibrotic area (arrow). Note the presence of myocytes with extensive degenerative changes, demonstrating disorganized cytoplasmic expression of vinculin (arrowheads). Counterstained with eosin (200x).