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Figure 1 Structural alterations of the myocytes and the cardiac interstitium in dysfunctional myocardial segments. (A) Segment with preserved function showing relatively few morphologic abnormalities. (B) Segment with reversible dysfunction demonstrating a widened interstitial space (arrows), with a relatively high cellular content, and myocyte degeneration with significant loss of contractile material (arrowheads). (C) Segments with persistent dysfunction after revascularization show more extensive pathologic changes, severe sarcomeric loss and significant extracellular matrix accumulation in the cardiac interstitium. All slides were stained with hematoxylin-eosin (400x).