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Figure 2 Left ventricular (LV) angiotensin (ANG) II concentrations and LV angiotensin-converting enzyme (ACE) activity levels in normal, mitral regurgitation (MR) and MR+AT₁RB dogs demonstrating that ANG II and ACE were increased greater than twofold in MR dogs vs. normals, but were normalized by AT₁RB. *p < 0.05 MR vs. normal dogs. AT₁RB = angiotensin II type-1 receptor blocker.