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Figure 3 Infarct area (IA) and area at risk (AAR) of the left ventricle (LV) after 30-min ligation and 120-min reperfusion. Representative photographs of midventricular myocardium from wild-type mice(A), tumor necrosis factor (TNF)- knockout (KO) mice (B), wild-type mice receiving nonimmune IgG (C) and wild-type mice receiving anti-TNF- antibody (D). (E) Summarized data on infarct area to area at risk ratio (IA/AAR), IA to left ventricle ratio (IA/LV) and AAR to LV ratio (AAR/LV) in wild-type (n = 11) and TNF- KO (n = 9) mice. (F) Summarized data on IA/AAR, IA/LV and AAR/LV in wild-type mice receiving nonimmune IgG (n = 5) and anti-TNF- antibody (n = 5). **p < 0.01.