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Figure 3 Photomicrographs of formalin-fixed, paraffin-embedded rabbit coronary artery tissue stained with Movat’s pentachrome, showing type I to V lesions. The bars represent 100 µm (A–C) or 200 µm (D, E). The type I lesion (A) showed intimal thickening, with an increase in the number of intimal macrophages, as well as isolated, small groups of foam cells. The type II lesion showed layers of foam cells and lipids within intimal smooth muscle cells (B). The type III lesion showed extracellular lipid pools (C), and the type IV lesion showed a larger, more confluent and disruptive core of extracellular lipids (D). The type V lesion showed thick layers of fibrous connective tissue, in addition to the lipid core (E).