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Figure 3 Bar graphs illustrating the effect of the pulsing interval (PI) on extravasation point creation and fluorescent polymer microsphere delivery to muscle. (A) Mean gray-scale level above baseline and the number of extravasation points per unit surface area after a 40-s arterial injection, as a function of PI. No significant differences were observed at p < 0.05. (B) Data in part A normalized to the number of applied ultrasound pulses. *p < 0.05 versus 1-s PI. **p < 0.05 versus 5-s PI.