Click on image to view larger version.

Figure 4 Effects of dichloroacetate (DCA) on cumulative glycolysis, glucose oxidation and H⁺ production from glucose metabolism during reperfusion of ischemic hearts in the presence of 1.2 mmol/l palmitate. Values are means ± SEM of eight glucose+palmitate perfused hearts (closed circles) and eight glucose+palmitate+DCA perfused hearts (closed triangles). Hearts were subjected to 30 min of aerobic perfusion, 20 min of global no-flow ischemia and 40 min of aerobic reperfusion. Pre-ischemic values were taken at 30 min of aerobic perfusion. Values were determined between 10 and 40 min of reperfusion. Dichloroacetate (3 mmol/l), when present, was added immediately before reperfusion. *Significant time-treatment interaction as determined by two-way analysis of variance with repeated measures on time. After application of the Huyhn-Feldt correction, p values for the time-treatment interactions for glycolysis, glucose oxidation and proton production are 0.345, <0.0001 and 0.029, respectively.