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Figure 2 To analyze the correlation between the development of intimal thickening and ET-1 ligand and receptor expression, allograft recipients were given CsA at a dose of either 1.0, 1.5 or 2 mg/kg per day for two weeks, followed by one week of CsA at 1 mg/kg per day. The correlation of intimal thickening with ET-1 (left column), ET_A (middle column) and ET_B (right column) protein expression in the arterial wall of chronically rejecting allografts, analyzed by linear regeression analysis. Correlation coefficients (r²) are given. Immunohistochemistry findings were scored from 0 to 3 (0 = no visible staining; 1 = few cells with faint staining; 2 = moderate intensity with multifocal staining; and 3 = intense diffuse staining of the cells).