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Figure 2 Left ventricular systolic function in rats with POH. The ex vivo pressure–volume relationship in the POH-HF and POH-NHF groups exhibits a progressive rightward shift that is most prominent in the group with heart failure (top). The slope of this relationship (E) is significantly lower (50%) in the POH-HF group than in the control group, although the small reduction (15%) in the POH-NHF group is not significantly less. *p < 0.05 vs. control and POH-NHF groups. LVP = left ventricular pressure; V = volume; other abbreviations as in Figure 1.