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Figure 1 (A) Effects of the indicated dilutions of CE on isolated, field-stimulated rat cardiomyocytes. The CE was collected on day 1 during the first regeneration cycle of IA, session 1. Changes of Ca²⁺ transients (peak systolic rfu – diastolic rfu) (left plot) and systolic cell shortening (right plot) during superfusion of CE from healthy blood donors (control subjects = solid squares, n = 9) and of CE from patients with DCM (solid triangles, n = 11). Data (percent changes from baseline) are presented as the mean value ± SEM. *p < 0.05, **p < 0.01 and *** p < 0.001 vs. control subjects. (B) Correlation of effects of CE (collected on day 1, dilution 1:5) from patients with DCM on Ca²⁺ transients and systolic cell shortening of isolated, field-stimulated rat cardiomyocytes, with the increase in CI during session 1 of IA. CI = confidence interval.