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Figure 4 Diagram pertaining to free fatty acid (FFA), endothelin-1 (ET-1), nitric oxide (NO) and lactate levels (mean values ± SE) 15 min before exercise testing, at time 0, at peak exercise and 10, 15 and 20 min after exercise testing, during saline and heparin, with placebo and trimetazidine (TMZ). Solid circles = saline and placebo; striped squares = heparin and placebo; checkered squares = heparin and TMZ; open circles = saline and TMZ. *p < 0.01 versus saline and placebo and versus heparin and placebo. #p < 0.01 versus time 0. p < 0.01 versus heparin and placebo and versus heparin and TMZ. p < 0.05 versus heparin and placebo.