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Figure 2 Production of superoxide anion (O₂^–) (lucigenin 5 µmol/l) in the aortic rings of rats with congestive heart failure (CHF) at 12 weeks after myocardial infarction, as compared with sham-operated animals (for experimental groups, see Fig. 1). Data are presented as the mean value ± SEM from 8 to 10 separate experiments. **p < 0.01 CHF/placebo group vs. sham/placebo group. p < 0.01 CHF/spironolactone (SP) group and CHF/trandolapril (TR)-SP group vs. CHF/placebo group.