Click on image to view larger version.

Figure 1 Relaxations induced by acetylcholine (A) and sodium nitroprusside (B) in the aortic rings of rats with congestive heart failure (CHF) at 12 weeks after myocardial infarction (solid circles, diamonds, triangles and squares), as compared with sham-operated animals (open circles). The animals were treated with either placebo (Plac; solid and open circles), trandolapril (TR) (0.3 mg/kg body weight per day; solid diamonds), spironolactone (SP) (10 mg/kg per day; solid triangles) or a combination of TR and spironolactone (SP) (solid squares). Data are presented as the mean value ± SEM from 8 to 10 separate experiments. **p < 0.01 CHF/placebo group vs. sham/placebo group and CHF/TR-SP group.