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Figure 1 Change from pretreatment day 1 baseline levels in pulmonary capillary wedge pressure (PCWP) (a) and systolic blood pressure (SBP) (b) after the final dose of omapatrilat at 12 weeks. Panel I: open diamond = 2.5 mg; star = 5 mg; open triangle = 10 mg. Panel II: + = 2.5 mg; open square = 20 mg; open circle = 40 mg. Shaded symbols indicate a significant difference (p < 0.05) in the 0-h to 12-h average change from predose day 1 for omapatrilat dose compared with the respective 2.5 mg group.