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Figure 2 Light micrographs of the lungs at 48 h after myocardial infarction (MI) or sham operation. Tezosentan (10 mg/kg, IV; MI + tezo) or vehicle (saline, 1 ml/kg, IV; MI + veh) was injected at 1 h and 24 h after MI. Tezosentan largely prevented the lung damage (overt capillary dilation and eosin-like edematous materials) seen in the vehicle-treated MI rats (MI + veh). In sham-operated rats (Sham), no pulmonary capillary dilation or edema was observed at 48 h after operation. Hematoxillin eosin stain, x 100.