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Figure 4 Relaxations induced by acetylcholine (A) and sodium nitroprusside (SNP) (B) in phenylephrine-preconstricted aortic rings from rats 2 h after myocardial infarction (), as compared with sham-operated animals (solid and open circles). The rats were treated with either vehicle (open circles and open downward triangles) or SR141716A (6.45 µmol/kg intravenous 15 min before myocardial infarction (solid circles and). The results are expressed as the mean value ± SEM from 8 to 12 separate experiments. **p < 0.01 for vehicle used in rats with myocardial infarction vs. vehicle used in sham-operated rats vs. SR141716A used in rats with myocardial infarction.