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Figure 1 The effects of myocardial infarction on mean arterial pressure (A) and heart rate (B) in control rats (circles; n = 16) or SR141716A-pretreated (circles, n = 12) rats. SR141716A (6.45 µmol/kg IV) was given 15 min before left coronary artery ligation, performed at 0 min. The vertical bars represent SEM. Significant differences (*p < 0.05; p < 0.01; #p < 0.001) from corresponding values in the absence of SR141716A .